- Office.Room 205, Advanced Materials & Chemical Engineering Building
- Tel.02-2220-0483
- Email.munsy@hanyang.ac.kr
- Website.Advanced Bio & Pharmaceutical Separation Process Lab.
Bioseparation process development
Pharmaceutical purification process development
Simulated Moving Bed (SMB) separation technology
SMB process development
Chromatographic separation processes
Adsorption separation processes
Ion-exchange
Carousel process
Process modeling
Computer simulation
Process optimization
Process scale-up
Introduction to Chemical Engineering Design
Transport Phenomena
Comprehensive Design in Chemical Engineering
Advanced Continuous Separation Processes
B.S., Hanyang University, Korea, 1997
M.S., KAIST, Korea, 1999
Ph.D., Purdue University , U.S.A., 2002
1999.08 ~ 2002.12 Research Assistant, Purdue University, USA
2000.08 ~ 2002.05 Teaching Assistant, Purdue University, USA
2003.01 ~ 2004.07 Postdoctorial Research Associate, Purdue University, USA
2004.09 ~ present Professor, Dept. of Chem. Eng., Hanyang University, Korea
Jo, CY., Mo, HK., Lee, KB., Mun, S. Optimal design of a simulated-moving-bed separation process for economical production of xylitol from bamboo-hydrolysis byproducts. Separation and Purification Technology (2024). https://doi.org/10.1016/j.seppur.2023.125828
Kang, H-J., Jo, CY., Mun, S. Improving the economical efficiency of a simulated-moving-bed process for biofuel production from agarose in red algae. Chemical Engineering Journal (2023). https://doi.org/10.1016/j.cej.2023.144884
Jo, CY., Lee, K., Lee, C-G., Kim, K., Mun, S. Development of a stepwise solvent-gradient SMB process for continuous-mode purification of methoxyethyl nucleoside phosphoramidites to be used as the key building blocks of oligonucleotide drugs. Chemical Engineering Journal (2023). https://doi.org/10.1016/j.cej.2023.143990
Kang, H-J., Jo, CY., Mun, S. Strategies to reduce the extent of product dilution in a tandem simulated-moving-bed process for ternary separation without loss of throughput. Applied Energy (2023). https://doi.org/10.1016/j.apenergy.2022.120376
Jo, CY., Kang, H-J., Mun, S. Improving the performances of a simulated-moving-bed reactor for the synthesis of methyl acetate ester by using partial port-closing strategies. Chemical Engineering Journal (2022). https://doi.org/10.1016/j.cej.2022.134887
Park, H., Jo, CY., Lee, KB., Mun, S. Standing wave design and optimization of a tandem size- exclusion simulated moving bed process for high-throughput recovery of neoagarohexaose from neoagarooligosaccharides. Separation and Purification Technology (2021). https://doi.org/10.1016/j.seppur.2021.119039
Park, H., Kim, JW., Chang, YK., Mun, S. The first attempt at simulated-moving-bed separation of medically utilizable ingredients from neoagarooligosaccharides generated through the β-agarase hydrolysis of agarose in red algae. Separation and Purification Technology (2021). https://doi.org/10.1016/j.seppur.2021.118604
Jo, CY., Choi, J-H., Kim, JW., Mun, S. Development of a simulated moving bed process for ultra-high-purity separation of ribose from a low-selectivity sugar mixture in microalgal hydrolysate. Separation and Purification Technology (2021). https://doi.org/10.1016/j.seppur.2020.118298
Yoon, HJ., Mun, S., Lee, KB. Facile reactivation of used CaO-based CO2 sorbent via physical treatment: Critical relationship between particle size and CO2 sorption performance. Chemical Engineering Journal (2021). https://doi.org/10.1016/j.cej.2020.127234
Lee, C-G., Jo, CY., Lee, KB., Mun, S. Optimization of a simulated-moving-bed process for continuous separation of racemic and meso-2,3-butanediol using an efficient optimization tool based on nonlinear standing-wave-design method. Separation and Purification Technology (2021). https://doi.org/10.1016/j.seppur.2020.117597
The Advanced Bio & Pharmaceutical Separation Process Laboratory conducts fundamental and applied research aimed at developing high-purity separation and purification processes for end products in high-value industries. Based on these studies, the laboratory pursues the development of industrial-scale separation and purification processes for promising future bio and pharmaceutical raw materials. In particular, the lab is developing high-efficiency novel processes capable of large-scale, high-purity recovery of major high-value compounds for which high-purity production has not yet been attempted. Our previous research includes the development of “Simulated Moving Bed (SMB) processes for continuous high-purity recovery of prebiotic components in oligosaccharides”, “High-purity large-scale recovery processes for valuable compounds in marine biomass (such as liver disease treatments, cardiovascular therapeutics, cosmetics, and human milk substitutes)”, “Carousel processes for continuous high-purity recovery of valuable heavy metals and rare earth elements”, “High-purity production processes for anticancer compounds derived from natural products”, and “SMB-based continuous separation processes for high-purity purification of products from chemically synthesized drug manufacturing processes”. More recently, the lab has been focusing on developing high-purity and high-efficiency separation and purification processes for mRNA raw materials used in COVID-19 vaccines. In addition, we are conducting research on process optimization, advanced design methodologies, and scale-up techniques for a wide range of separation and purification processes. Through these efforts, we aim to establish a system that enables rapid translation of laboratory-scale results into industrial-scale processes. The research activities of our laboratory are expected to make significant contributions to improving the efficiency and economic feasibility of high-value product manufacturing in the domestic bio and pharmaceutical industries. Furthermore, our work aims to provide core process technologies that will serve as a foundation for the large-scale, high-purity production of global pharmaceuticals and new drugs.